The ABC transporters in Candidatus Liberibacter asiaticus
Identifieur interne : 001457 ( Main/Exploration ); précédent : 001456; suivant : 001458The ABC transporters in Candidatus Liberibacter asiaticus
Auteurs : Wenlin Li [États-Unis] ; Qian Cong [États-Unis] ; Jimin Pei [États-Unis] ; Lisa N. Kinch [États-Unis] ; Nick V. Grishin [États-Unis]Source :
- Proteins: Structure, Function, and Bioinformatics [ 0887-3585 ] ; 2012-11.
English descriptors
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Abstract
Candidatus Liberibacter asiaticus (Ca. L. asiaticus) is a Gram‐negative bacterium and the pathogen of Citrus Greening disease (Huanglongbing, HLB). As a parasitic bacterium, Ca. L. asiaticus harbors ABC transporters that play important roles in exchanging chemical compounds between Ca. L. asiaticus and its host. Here, we analyzed all the ABC transporter‐related proteins in Ca. L. asiaticus. We identified 14 ABC transporter systems and predicted their structures and substrate specificities. In‐depth sequence and structure analysis including multiple sequence alignment, phylogenetic tree reconstruction, and structure comparison further support their function predictions. Our study shows that this bacterium could use these ABC transporters to import metabolites (amino acids and phosphates) and enzyme cofactors (choline, thiamine, iron, manganese, and zinc), resist to organic solvent, heavy metal, and lipid‐like drugs, maintain the composition of the outer membrane (OM), and secrete virulence factors. Although the features of most ABC systems could be deduced from the abundant experimental data on their orthologs, we reported several novel observations within ABC system proteins. Moreover, we identified seven nontransport ABC systems that are likely involved in virulence gene expression regulation, transposon excision regulation, and DNA repair. Our analysis reveals several candidates for further studies to understand and control the disease, including the type I virulence factor secretion system and its substrate that are likely related to Ca. L. asiaticus pathogenicity and the ABC transporter systems responsible for bacterial OM biosynthesis that are good drug targets. Proteins 2012. © 2012 Wiley Periodicals, Inc.
Url:
- https://api.istex.fr/document/553DACB1B5EE38E509364FD380E2484E548AACB9/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688454
DOI: 10.1002/prot.24147
Affiliations:
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Grishin</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Department of Biochemistry and Department of Biophysics, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Proteins: Structure, Function, and Bioinformatics</title><title level="j" type="abbrev">Proteins</title><idno type="ISSN">0887-3585</idno><idno type="eISSN">1097-0134</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2012-11">2012-11</date><biblScope unit="volume">80</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="2614">2614</biblScope><biblScope unit="page" to="2628">2628</biblScope></imprint><idno type="ISSN">0887-3585</idno></series><idno type="istex">553DACB1B5EE38E509364FD380E2484E548AACB9</idno><idno type="DOI">10.1002/prot.24147</idno><idno type="ArticleID">PROT24147</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0887-3585</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ATPase</term><term>function prediction</term><term>genomic annotation</term><term>multiple sequence alignment</term><term>phylogenetic tree</term><term>protein homology</term><term>structure comparison</term><term>transmembrane protein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Candidatus Liberibacter asiaticus (Ca. L. asiaticus) is a Gram‐negative bacterium and the pathogen of Citrus Greening disease (Huanglongbing, HLB). As a parasitic bacterium, Ca. L. asiaticus harbors ABC transporters that play important roles in exchanging chemical compounds between Ca. L. asiaticus and its host. Here, we analyzed all the ABC transporter‐related proteins in Ca. L. asiaticus. We identified 14 ABC transporter systems and predicted their structures and substrate specificities. In‐depth sequence and structure analysis including multiple sequence alignment, phylogenetic tree reconstruction, and structure comparison further support their function predictions. Our study shows that this bacterium could use these ABC transporters to import metabolites (amino acids and phosphates) and enzyme cofactors (choline, thiamine, iron, manganese, and zinc), resist to organic solvent, heavy metal, and lipid‐like drugs, maintain the composition of the outer membrane (OM), and secrete virulence factors. Although the features of most ABC systems could be deduced from the abundant experimental data on their orthologs, we reported several novel observations within ABC system proteins. Moreover, we identified seven nontransport ABC systems that are likely involved in virulence gene expression regulation, transposon excision regulation, and DNA repair. Our analysis reveals several candidates for further studies to understand and control the disease, including the type I virulence factor secretion system and its substrate that are likely related to Ca. L. asiaticus pathogenicity and the ABC transporter systems responsible for bacterial OM biosynthesis that are good drug targets. Proteins 2012. © 2012 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Li, Wenlin" sort="Li, Wenlin" uniqKey="Li W" first="Wenlin" last="Li">Wenlin Li</name></region><name sortKey="Cong, Qian" sort="Cong, Qian" uniqKey="Cong Q" first="Qian" last="Cong">Qian Cong</name><name sortKey="Grishin, Nick V" sort="Grishin, Nick V" uniqKey="Grishin N" first="Nick V." last="Grishin">Nick V. Grishin</name><name sortKey="Grishin, Nick V" sort="Grishin, Nick V" uniqKey="Grishin N" first="Nick V." last="Grishin">Nick V. Grishin</name><name sortKey="Kinch, Lisa N" sort="Kinch, Lisa N" uniqKey="Kinch L" first="Lisa N." last="Kinch">Lisa N. Kinch</name><name sortKey="Pei, Jimin" sort="Pei, Jimin" uniqKey="Pei J" first="Jimin" last="Pei">Jimin Pei</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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